From Bozen/Bolzano towards Brenner pass (autobahn toll) and on the A 13 to the toll station in Schönberg - direction Innsbruck. In Innsbruck you take the A 12 towards Bregenz (autobahn toll sticker required) until you reach the exit "Ötztal". Then follow B 186 federal road into Ötztal.
In the summer months from early June to late October, coming from Meran on the SS44 federal road in the direction of St. Leonhard im Passeier | Moos im Passeier, you can reach Hochgurgl and Obergurgl on the B186 federal road via the Timmelsjoch High Alpine Road (toll road, please check opening times, CLOSED ALL WINTER!) between 7.00 am and 8.00 pm.